名字：侯德富

照片：

职称：副教授

专业：医学检验技术、病理学与病理生理学

电子邮箱：defuhou@hunnu.edu.cn

通讯地址：js555888金沙老品牌生物化学与分子生物教研室，邮编：410013

简介：

侯德富，中南大学湘雅js555888金沙老品牌医学博士，美国路易斯安那州立大学访问学者，js555888金沙老品牌副教授，硕士研究生导师。承担各专业本科生《生物化学与分子生物学》理论和实验教学，留学生《biochemistry》全英文理论和实验教学。从事肿瘤发生的分子机制及肿瘤相关基因表达调控的分子机制、肿瘤药物耐受机制及其治疗等方面的研究工作。先后主持并完成教育部留学归国基金、湖南省自然科学基金、湖南省教育厅自然科学研究项目、js555888金沙老品牌博士启动基金、js555888金沙老品牌青年基金、校级教改课题及精品课程等项目。

代表性学术论文：

1.Lyu H,Hou D, Liu H, Ruan S, Tan C, Wu J, Hicks C, Liu B. HER3 targeting augments the efficacy of panobinostat in claudin-low triple-negative breast cancer cells. NPJ Precis Oncol. 2023 Aug 3;7(1):72.

2.Zhong W, Shen Z, Wang M, Wang H, Sun Y, Tao X*,Hou D*. Tumor Microenvironment Responsive Nanomicelle with Folic Acid Modification Co-Delivery of Doxorubicin/Shikonin for Triple Negative Breast Cancer Treatment.Pharmaceuticals. 2023; 16(3):374.

3.Yi Zhang, Qing Jiang, Xinyi Liu, Liping Peng, Xinyi Tang, Ling Li, Xiao Ling, Xiaoping Yang, Chunlian He, Xiaojun Tao*,Defu Hou*. A Study of Hydrophobically Modified Pullulan Nanoparticles with Different Hydrophobic Densities on the Effect of Anti-Colon Cancer Cell Efficienc. J Biomed Nanotechnol . 2021 Oct 1; 17(10): 1972-1983.

4.Shuang Liu, Erik V Polsdofer, Lukun Zhou, Sanbao Ruan, Hui Lyu,Defu Hou,Hao Liu, Ann D Thor, Zhimin He, Bolin Liu.Upregulation of endogenous TRAIL-elicited apoptosis is essential for metformin-mediated antitumor activity against TNBC and NSCLC. Mol Ther Oncolytics . 2021 Apr 29; 21: 303-314.

5.侯德富,关瑞,万恂恂,陈主初.NFY结合位点缺失下调NPCEDRG基因启动子转录活性和效率.中国生物化学与分子生物学报, 2013, 29(12): 1159-1165.

6.GUAN Rui,HOU De-Fu, RAO Xiang, GUAN Yong-Jun, OUYANG Yong-Mei, YU Yan-Hui, HU Jim, CHEN Zhu-Chu. ZNF403, a novel cell cycle regulator.生物化学与生物物理学进展, 2013, 40(2): 147-158.

7.Guan R,Wen XY,Wu J,Duan R,Cao H,Lam S,Hou D,Wang Y,Hu J,Chen Z.Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators.Mol Cell Biochem.2012, 365(1-2):211-22.

8.Hou D, Guan Y, Liu J, Xiao Z, Ouyang Y, Yu Y, Chen Z.Cloning and characterization of the NPCEDRG gene promoter. Mol Cell Biochem. 2011, 346(1-2): 1-10.

9.侯德富,关勇军,关瑞,欧阳咏梅,余艳辉,陈主初.人NPCEDRG基因启动子的克隆及CCAAT/NFY结合位点初步分析。生物化学与生物物理学进展，2011, 38(8): 713-723.

10.He Q, Zhang G,Hou D, Leng A, Xu M, Peng J, Liu T. Overexpression of sorcin results in multidrug resistance in gastric cancer cells with up-regulation of P-gp. Oncol Rep. 2011, 25(1): 237-43.

11.Hou DF, Wang SL, He ZM, Yang F, Chen ZC. Expression of CYP2E1 in human nasopharynx and its metabolic effectin vitro. Mol Cell Biochem.2007, 298(1-2): 93-100.